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KMID : 0043320080310050622
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Archives of Pharmacal Research
2008 Volume.31 No. 5 p.622 ~ p.627
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The Effects of Fucoidan Extracts on CCl₄-Induced Liver Injury
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Kang Kum-Suk
Kim In-Deok
Kwon Ryun-Hee
Lee Jin-Young
Kang Jae-Seon
Ha Bae-Jin
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Abstract
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The aim of this study was to elucidate the antioxidant properties of fucoidan extracts (FE) against -induced oxidative stress by monitoring the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Female, Sparague-Dowley rats were administered with FE (100 mg/kg daily) for 14 days and on the 15’th day, 12 h before they were sacrificed. The levels of GOT, GPT, ALP and LDH in serum of rats, as well as the levels of MDA, SOD, CAT and GPx in total liver homogenate were analyzed. -treatment was found to increase the levels of GOT, GPT, ALP, LDH and MDA, as well as decrease levels of SOD, CAT and GPx significantly. The pre-treatment of rats with FE, however, suppressed the increment of levels of GOT, GPT, ALP, LDH and MDA, as well as recovered the levels of SOD, CAT and GPx in CCl4-treated rats. Moreover there was a significant decrease in incidences of necrosis and cirrhosis in the liver tissue of FE-treated rats. These results implied that FE possessed antioxidant properties against -induced oxidative stress.
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KEYWORD
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Undaria pinnatipida sporophylls, Laminaria japonica, Fucoidan, Oxidative stress, Antioxidative enzymes
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